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Additionally, individuals dealing with insulin resistance or prediabetes often respond exceptionally well once the medication helps stabilize their blood sugar

Besides, trigonelline displayed great potential in treating obesity as it is involved in the browning of 3T3-L1 white adipocytes

By restraining NRF2 activity, GSH synthesis facilitates the expression of lipogenic enzymes and enables the supply of triglycerides into circulation

In addition, age dependent accretion of dysfunctional mitochondria elevates stress level, which is exhibited by high levels oxidized products such as protein carbonyls and lipid peroxides 42

PT-141 was developed as the safer, more targeted alternative